The Effects of ISM1 Medium on Embryo Quality and Outcomes of IVF/ICSI Cycles
نویسندگان
چکیده
BACKGROUND The aim of this study is to investigate the effect of ISM1 culture medium on embryo development, quality and outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles. This study compares culture medium commonly used in the laboratory setting for oocyte recovery and embryo development with a medium from MediCult. We have assessed the effects of these media on embryo development and newborn characteristics. MATERIALS AND METHODS In this prospective randomized study, fertilized oocytes from patients were randomly assigned to culture in ISM1 (MediCult, cycles: n=293) or routine lab culture medium (G-1TM v5; Vitrolife, cycles: n=290) according to the daily media schedule for oocyte retrieval. IVF or ICSI and embryo transfer were performed with either MediCult media or routine lab media. Embryo quality on days 2/3, cleavage, pregnancy and implantation rates, baby take home rate (BTHR), in addition to the weight and length of newborns were compared between groups. RESULTS There were similar cleavage rates for ISM1 (86%) vs. G-1TM v5 (88%). We observed a significantly higher percentage of excellent embryos in ISM1 (42.7%) compared to G-1TM v5 (39%, p<0.05). Babies born after culture in ISM1 had both higher birth weight (3.03 kg) and length (48.8 cm) compared to G-1TM v5 babies that had a birth weight of 2.66 kg and a length of 46.0 cm (p<0.001 for both). CONCLUSION This study suggests that ISM1 is a more effective culture medium in generating higher quality embryos, which may be reflected in the characteristics of babies at birth.
منابع مشابه
Pnm-30: Assessment of The Relationship between Embryo Quality after ICSI and IVF at The Second and Third Days after Fertilization with Mothers’ BMI
a:4:{s:10:"Background";s:513:"Obesity has become a major health problem across the world. In women, it is known to cause anovulation, sub-fecundity, increased risk of fetal anomalies and miscarriage rates. However, in women going for assisted reproduction the effects of obesity on egg quality, embryo quality, clinical pregnancy, live birth rates are controversial To assess the effect of women's...
متن کاملP-82: Antagonist/Letrozole Protocol in Poor Ovarian Responder Patients Undergoing Intracytoplasmic Sperm Injection- Embryo transfer Cycles
Background The optimal stimulation protocol for poor responder patients is a therapeutic challenge. GnRH antagonist protocol has been proposed as a potentially proper option for poor responders. Nevertheless, there is no significant difference in terms of clinical pregnancy and cancellation rates be tween the GnRH antagonist and agonist cycles. Therefore, this subset of patients might be the be...
متن کاملO-23: Hysteroscopic Polypectomy without Cycle Cancellation in IVF/ICSI Cycles: A Matched Case-Control Study
Background The effect of hysteroscopic polpectomy for endometrial polyps during treatment cycles is still debated and further studies are necessary to evaluate beneficial effect of this procedure. MaterialsAndMethods This matched case-control study compared retrospectively 86 women with and without hysteroscopic polypectomy who underwent in vitro fertilization and / or Intracytoplasmic sperm in...
متن کاملInfluence of the insemination method on the outcomes of elective blastocyst culture
OBJECTIVE The aim of this study was to explore the effects of the insemination method on the outcomes of elective blastocyst culture. METHODS We retrospectively analyzed the outcomes of elective blastocyst culture performed between January 2011 and December 2014. RESULTS There were 2,003 cycles of conventional in vitro fertilization (IVF) and 336 cycles of intracytoplasmic sperm injection (...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2013